| Peer-Reviewed

Association Between ABO-RHD Blood Groups and COVID-19: A Preliminary Study of 76 Cases

Received: 7 March 2023     Accepted: 6 April 2023     Published: 10 May 2023
Views:       Downloads:
Abstract

Introduction: Blood types are most often incriminated in susceptibility to COVID-19. Blood group O subjects are reportedly less susceptible to COVID-19. However, these reports are mainly from countries with high infection rates. The overall objective of this study was to investigate the association between the risk of COVID-19 infection, its severity, and ABO-RHD blood groups at the Training Hospitals of Bouake and Cocody (Ivory Coast). Material and methods: This was a prospective study that lasted four months. All patients with COVID-19 at the time of the study and followed at the Training Hospitals of Bouake and Cocody, hospitalized in the COVID-19 centers or in home confinement, were included. T lymphocyte subpopulations were counted on the BD FACS Calibur flow cytometer after labeling. ABO and RHD blood typing was performed in all patients. Results: Of the 76 patients collected, 78.9% were homebound, 18.4% in hospital and 2.6% in the ICU. The mean age was 41.92 ± 15.13 years with a male predominance. The majority of hospitalized patients were significantly of blood group A (p=0.020). CD4 and CD8 T lymphopenia were significantly more frequent in patients with blood group A than in those with blood groups B, AB and O. Conclusion: The impact of blood group on the severity of the disease would exist. Our study showed that blood group A subjects were more likely to have COVID-19. In addition, a statistically significant association between blood type A and CD4 and CD8 T lymphopenia was found. These results should be confirmed by studies based on larger patient samples.

Published in International Journal of Immunology (Volume 11, Issue 1)
DOI 10.11648/j.iji.20231101.11
Page(s) 1-5
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Lymphopenia, CD4, CD8, COVID-19, ABO-RHD Blood Groups

References
[1] Abdelmalek R. COVID-19, chroniques d’une pandémie annoncée COVID-19, chronicles of a forecasted pandemic.: 4.
[2] Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China. Clin Infect Dis Off Publ Infect Dis Soc Am. 28 juill 2020; 71 (15): 762-8.
[3] Zhou X, Ye Q. Cellular Immune Response to COVID-19 and Potential Immune Modulators. Front Immunol [Internet]. 2021 [cité 20 janv 2022]; 12. Disponible sur: https://www.frontiersin.org/article/10.3389/fimmu.2021.646333
[4] Planté-Bordeneuve T, Froidure A, Pilette C. Immunité et COVID-19 : état des lieux, vers une médecine de précision ?: 7.
[5] Zhao Q, Meng M, Kumar R, Wu Y, Huang J, Deng Y, et al. Lymphopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A systemic review and meta-analysis. Int J Infect Dis. juill 2020; 96: 131-5.
[6] Huang W, Berube J, McNamara M, Saksena S, Hartman M, Arshad T, et al. Lymphocyte Subset Counts in COVID-19 Patients: A Meta-Analysis. Cytom Part J Int Soc Anal Cytol. août 2020; 97 (8): 772-6.
[7] Goel R, Bloch EM, Pirenne F, Al-Riyami AZ, Crowe E, Dau L, et al. ABO blood group and COVID-19: a review on behalf of the ISBT COVID-19 Working Group. Vox Sang. 2021; 116 (8): 849-61.
[8] Bourhanbour AD, Bakkouri JE. CONNAISSANCES ACTUELLES DE L’IMMUNOPATHOLOGIE DU COVID-19. Rev Marocaine Santé Publique [Internet]. 18 mai 2020 [cité 20 janv 2022]; 7 (10). Disponible sur: https://revues.imist.ma/index.php/RMSP/article/view/20927
[9] Liu N, Zhang T, Ma L, Zhang H, Wang H, Wei W, et al. The impact of ABO blood group on COVID-19 infection risk and mortality: A systematic review and meta-analysis. Blood Rev. juill 2021; 48: 100785.
[10] Hardy ÉJL, Flori P. Spécificités épidémiologiques de la COVID-19 en Afrique: préoccupation de santé publique actuelle ou future ? Ann Pharm Fr. 1 mars 2021; 79 (2): 216-26.
[11] Dosi R, Jain G, Mehta A. Clinical Characteristics, Comorbidities, and Outcome among 365 Patients of Coronavirus Disease 2019 at a Tertiary Care Centre in Central India. J Assoc Physicians India. 1 sept 2020; 68 (9): 20-3.
[12] Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet Lond Engl. 15 févr 2020; 395 (10223): 497-506.
[13] Donamou J, Bangoura A, Camara LM, Camara D, Traoré DA, Abékan RJM, et al. Caractéristiques épidémiologiques et cliniques des patients COVID-19 admis en réanimation à l’hôpital Donka de Conakry, Guinée: étude descriptive des 140 premiers cas hospitalisés. Anesth Réanimation. 1 mars 2021; 7 (2): 102-9.
[14] Eboko F, Schlimmer S. COVID-19: l’Afrique face à une crise mondiale. Polit Étrangère. 2020; Hiver (4): 123-34.
[15] COVID-19: quelles classes d’âge portent la reprise épidémique? [Internet]. BFMTV. [cité 5 mars 2022]. Disponible sur: https://www.bfmtv.com/sante/COVID-19-quelles-classes-d-age-portent-la-reprise-epidemique_AV-202111120148.html
[16] Masson E. Études preliminaires : caractéristiques épidémiologiques, cliniques et radiologiques des patients atteints de pneumonie à SARS-CoV2 au service de pneumo-phtisiologie du CHU Treichville [Internet]. EM-Consulte. [cité 19 janv 2022]. Disponible sur: https://www.em-consulte.com/article/1419490/etudes-preliminaires-caracteristiques-epidemiolog
[17] Moueden MA, Benlaldj D, Messaoudi R, Seghier F. Profil hématologique des patients atteints de COVID 19 au niveau du CHU d’Oran en Algérie. Algerian J Health Sci. 30 mars 2021; 3 (2): 22-9.
[18] COVID-19: le système immunitaire des femmes est-il plus robuste que celui des hommes? BBC News Afrique [Internet]. [cité 19 janv 2022]; Disponible sur: https://www.bbc.com/afrique/monde-54526559
[19] Dimassi I, Mahjoub S, Cherni R, Baccouche H, Chakroun A, Ben Romdhane N. Groupe sanguin ABO et sévérité de la COVID-19: étude monocentrique. Transfus Clin Biol. 1 nov 2021; 28 (4, Supplement): S115-6.
[20] Kibler M, Dietrich L, Kanso M, Carmona A, Marchandot B, Matsushita K, et al. Risk and Severity of COVID-19 and ABO Blood Group in Transcatheter Aortic Valve Patients. J Clin Med. 22 nov 2020; 9 (11): 3769.
[21] Li J, Wang X, Chen J, Cai Y, Deng A, Yang M. Association between ABO blood groups and risk of SARS-CoV-2 pneumonia. Br J Haematol. 26 mai 2020; 10.1111/bjh.16797.
[22] Ray JG, Schull MJ, Vermeulen MJ, Park AL. Association Between ABO and Rh Blood Groups and SARS-CoV-2 Infection or Severe COVID-19 Illness : A Population-Based Cohort Study. Ann Intern Med. mars 2021; 174 (3): 308-15.
Cite This Article
  • APA Style

    Adou Adjoumanvoule Honore, Siransy Kouabla Liliane, Memel Lasme Roselle Charline, Yeboah Oppong Richard, Goran-Kouacou Amah Patricia, et al. (2023). Association Between ABO-RHD Blood Groups and COVID-19: A Preliminary Study of 76 Cases. International Journal of Immunology, 11(1), 1-5. https://doi.org/10.11648/j.iji.20231101.11

    Copy | Download

    ACS Style

    Adou Adjoumanvoule Honore; Siransy Kouabla Liliane; Memel Lasme Roselle Charline; Yeboah Oppong Richard; Goran-Kouacou Amah Patricia, et al. Association Between ABO-RHD Blood Groups and COVID-19: A Preliminary Study of 76 Cases. Int. J. Immunol. 2023, 11(1), 1-5. doi: 10.11648/j.iji.20231101.11

    Copy | Download

    AMA Style

    Adou Adjoumanvoule Honore, Siransy Kouabla Liliane, Memel Lasme Roselle Charline, Yeboah Oppong Richard, Goran-Kouacou Amah Patricia, et al. Association Between ABO-RHD Blood Groups and COVID-19: A Preliminary Study of 76 Cases. Int J Immunol. 2023;11(1):1-5. doi: 10.11648/j.iji.20231101.11

    Copy | Download

  • @article{10.11648/j.iji.20231101.11,
      author = {Adou Adjoumanvoule Honore and Siransy Kouabla Liliane and Memel Lasme Roselle Charline and Yeboah Oppong Richard and Goran-Kouacou Amah Patricia and Kone Djakaridja and Kadiane N’Dri Juliette and Assi Aya Ursule Aniela and Gnemagnon Mahi Eric Constant and Ouattara Awa and Oura Brou Doris and Moussa Sali and Koya Hebert Gautier and Seri Yida Jocelyne and Aba Yapo Thomas and Krah Ouffoue},
      title = {Association Between ABO-RHD Blood Groups and COVID-19: A Preliminary Study of 76 Cases},
      journal = {International Journal of Immunology},
      volume = {11},
      number = {1},
      pages = {1-5},
      doi = {10.11648/j.iji.20231101.11},
      url = {https://doi.org/10.11648/j.iji.20231101.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20231101.11},
      abstract = {Introduction: Blood types are most often incriminated in susceptibility to COVID-19. Blood group O subjects are reportedly less susceptible to COVID-19. However, these reports are mainly from countries with high infection rates. The overall objective of this study was to investigate the association between the risk of COVID-19 infection, its severity, and ABO-RHD blood groups at the Training Hospitals of Bouake and Cocody (Ivory Coast). Material and methods: This was a prospective study that lasted four months. All patients with COVID-19 at the time of the study and followed at the Training Hospitals of Bouake and Cocody, hospitalized in the COVID-19 centers or in home confinement, were included. T lymphocyte subpopulations were counted on the BD FACS Calibur flow cytometer after labeling. ABO and RHD blood typing was performed in all patients. Results: Of the 76 patients collected, 78.9% were homebound, 18.4% in hospital and 2.6% in the ICU. The mean age was 41.92 ± 15.13 years with a male predominance. The majority of hospitalized patients were significantly of blood group A (p=0.020). CD4 and CD8 T lymphopenia were significantly more frequent in patients with blood group A than in those with blood groups B, AB and O. Conclusion: The impact of blood group on the severity of the disease would exist. Our study showed that blood group A subjects were more likely to have COVID-19. In addition, a statistically significant association between blood type A and CD4 and CD8 T lymphopenia was found. These results should be confirmed by studies based on larger patient samples.},
     year = {2023}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Association Between ABO-RHD Blood Groups and COVID-19: A Preliminary Study of 76 Cases
    AU  - Adou Adjoumanvoule Honore
    AU  - Siransy Kouabla Liliane
    AU  - Memel Lasme Roselle Charline
    AU  - Yeboah Oppong Richard
    AU  - Goran-Kouacou Amah Patricia
    AU  - Kone Djakaridja
    AU  - Kadiane N’Dri Juliette
    AU  - Assi Aya Ursule Aniela
    AU  - Gnemagnon Mahi Eric Constant
    AU  - Ouattara Awa
    AU  - Oura Brou Doris
    AU  - Moussa Sali
    AU  - Koya Hebert Gautier
    AU  - Seri Yida Jocelyne
    AU  - Aba Yapo Thomas
    AU  - Krah Ouffoue
    Y1  - 2023/05/10
    PY  - 2023
    N1  - https://doi.org/10.11648/j.iji.20231101.11
    DO  - 10.11648/j.iji.20231101.11
    T2  - International Journal of Immunology
    JF  - International Journal of Immunology
    JO  - International Journal of Immunology
    SP  - 1
    EP  - 5
    PB  - Science Publishing Group
    SN  - 2329-1753
    UR  - https://doi.org/10.11648/j.iji.20231101.11
    AB  - Introduction: Blood types are most often incriminated in susceptibility to COVID-19. Blood group O subjects are reportedly less susceptible to COVID-19. However, these reports are mainly from countries with high infection rates. The overall objective of this study was to investigate the association between the risk of COVID-19 infection, its severity, and ABO-RHD blood groups at the Training Hospitals of Bouake and Cocody (Ivory Coast). Material and methods: This was a prospective study that lasted four months. All patients with COVID-19 at the time of the study and followed at the Training Hospitals of Bouake and Cocody, hospitalized in the COVID-19 centers or in home confinement, were included. T lymphocyte subpopulations were counted on the BD FACS Calibur flow cytometer after labeling. ABO and RHD blood typing was performed in all patients. Results: Of the 76 patients collected, 78.9% were homebound, 18.4% in hospital and 2.6% in the ICU. The mean age was 41.92 ± 15.13 years with a male predominance. The majority of hospitalized patients were significantly of blood group A (p=0.020). CD4 and CD8 T lymphopenia were significantly more frequent in patients with blood group A than in those with blood groups B, AB and O. Conclusion: The impact of blood group on the severity of the disease would exist. Our study showed that blood group A subjects were more likely to have COVID-19. In addition, a statistically significant association between blood type A and CD4 and CD8 T lymphopenia was found. These results should be confirmed by studies based on larger patient samples.
    VL  - 11
    IS  - 1
    ER  - 

    Copy | Download

Author Information
  • Immunology-Allergology Department, Training Hospital of Cocody, Abidjan, Ivory Coast

  • Immunology-Allergology Department, Training Hospital of Cocody, Abidjan, Ivory Coast

  • Immunology Department, Training Hospital of Bouake, Ivory Coast

  • Immunology-Allergology Department, Training Hospital of Cocody, Abidjan, Ivory Coast

  • Immunology-Allergology Department, Training Hospital of Cocody, Abidjan, Ivory Coast

  • Infectious and Tropical Diseases Department, Training Hospital, Bouake, Ivory Coast

  • Infectious and Tropical Diseases Department, Training Hospital, Bouake, Ivory Coast

  • Immunology-Allergology Department, Training Hospital of Cocody, Abidjan, Ivory Coast

  • Infectious and Tropical Diseases Department, Training Hospital, Bouake, Ivory Coast

  • Infectious and Tropical Diseases Department, Training Hospital, Bouake, Ivory Coast

  • Immunology-Allergology Department, Training Hospital of Cocody, Abidjan, Ivory Coast

  • Immunology-Allergology Department, Training Hospital of Cocody, Abidjan, Ivory Coast

  • Immunology Department, Training Hospital of Bouake, Ivory Coast

  • Immunology-Allergology Department, Training Hospital of Cocody, Abidjan, Ivory Coast

  • Infectious and Tropical Diseases Department, Training Hospital, Bouake, Ivory Coast

  • Infectious and Tropical Diseases Department, Training Hospital, Bouake, Ivory Coast

  • Sections