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Diagnostic and Prognostic Value of Serum Calprotectin in Septic Shock Patients

Received: 27 May 2017     Accepted: 5 June 2017     Published: 10 July 2017
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Abstract

Calprotectin is a potent acute phase reactant with increases of more than 100 fold during inflamed conditions. We measured the diagnostic and prognostic value of serum calprotectin (SC) in septic shock. We enrolled 50 adult shocked patients admitted to intensive care unit. Then, classified into 2 groups; septic group (25) with well-defined septic shock with positive cultures. Non-septic group (25) with negative cultures or no source of sepsis. Blood samples for SC), C-reactive protein (CRP) and white blood cell count (WBCC) in the first 6 hours of ICU admission and re-obtained again on day 3. We observed the weaning of vasopressor and 7-days in ICU mortality. SC measured on day 1 was significantly higher in the septic group than the non-septic group (p<0.001). SC showed a good correlation with weaning of vasopressor (AUC was 0.764; p<0.028), while it showed relative correlation with 7-days in ICU mortality (AUC was 0.752; p<0.057) compared with other markers in the study. SC may aid in rapid identification of septic shock from non-septic shock at a cutoff of 2 µg/dl (sensitivity 92% and specificity 84%). Also the change in SC level may aid in prognostication of septic shock.

Published in Science Journal of Clinical Medicine (Volume 6, Issue 3)
DOI 10.11648/j.sjcm.20170603.11
Page(s) 32-38
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Critical, Septic Shock, Vasopressor, Mortality, Calprotectin, CRP

References
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Cite This Article
  • APA Style

    Mohamed Mostafa Megahed, Sherif Abdel-Fattah, Akram Refaie El-Sayed, Islam El Sayed Ahmed. (2017). Diagnostic and Prognostic Value of Serum Calprotectin in Septic Shock Patients. Science Journal of Clinical Medicine, 6(3), 32-38. https://doi.org/10.11648/j.sjcm.20170603.11

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    ACS Style

    Mohamed Mostafa Megahed; Sherif Abdel-Fattah; Akram Refaie El-Sayed; Islam El Sayed Ahmed. Diagnostic and Prognostic Value of Serum Calprotectin in Septic Shock Patients. Sci. J. Clin. Med. 2017, 6(3), 32-38. doi: 10.11648/j.sjcm.20170603.11

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    AMA Style

    Mohamed Mostafa Megahed, Sherif Abdel-Fattah, Akram Refaie El-Sayed, Islam El Sayed Ahmed. Diagnostic and Prognostic Value of Serum Calprotectin in Septic Shock Patients. Sci J Clin Med. 2017;6(3):32-38. doi: 10.11648/j.sjcm.20170603.11

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  • @article{10.11648/j.sjcm.20170603.11,
      author = {Mohamed Mostafa Megahed and Sherif Abdel-Fattah and Akram Refaie El-Sayed and Islam El Sayed Ahmed},
      title = {Diagnostic and Prognostic Value of Serum Calprotectin in Septic Shock Patients},
      journal = {Science Journal of Clinical Medicine},
      volume = {6},
      number = {3},
      pages = {32-38},
      doi = {10.11648/j.sjcm.20170603.11},
      url = {https://doi.org/10.11648/j.sjcm.20170603.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20170603.11},
      abstract = {Calprotectin is a potent acute phase reactant with increases of more than 100 fold during inflamed conditions. We measured the diagnostic and prognostic value of serum calprotectin (SC) in septic shock. We enrolled 50 adult shocked patients admitted to intensive care unit. Then, classified into 2 groups; septic group (25) with well-defined septic shock with positive cultures. Non-septic group (25) with negative cultures or no source of sepsis. Blood samples for SC), C-reactive protein (CRP) and white blood cell count (WBCC) in the first 6 hours of ICU admission and re-obtained again on day 3. We observed the weaning of vasopressor and 7-days in ICU mortality. SC measured on day 1 was significantly higher in the septic group than the non-septic group (p<0.001). SC showed a good correlation with weaning of vasopressor (AUC was 0.764; p<0.028), while it showed relative correlation with 7-days in ICU mortality (AUC was 0.752; p<0.057) compared with other markers in the study. SC may aid in rapid identification of septic shock from non-septic shock at a cutoff of 2 µg/dl (sensitivity 92% and specificity 84%). Also the change in SC level may aid in prognostication of septic shock.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Diagnostic and Prognostic Value of Serum Calprotectin in Septic Shock Patients
    AU  - Mohamed Mostafa Megahed
    AU  - Sherif Abdel-Fattah
    AU  - Akram Refaie El-Sayed
    AU  - Islam El Sayed Ahmed
    Y1  - 2017/07/10
    PY  - 2017
    N1  - https://doi.org/10.11648/j.sjcm.20170603.11
    DO  - 10.11648/j.sjcm.20170603.11
    T2  - Science Journal of Clinical Medicine
    JF  - Science Journal of Clinical Medicine
    JO  - Science Journal of Clinical Medicine
    SP  - 32
    EP  - 38
    PB  - Science Publishing Group
    SN  - 2327-2732
    UR  - https://doi.org/10.11648/j.sjcm.20170603.11
    AB  - Calprotectin is a potent acute phase reactant with increases of more than 100 fold during inflamed conditions. We measured the diagnostic and prognostic value of serum calprotectin (SC) in septic shock. We enrolled 50 adult shocked patients admitted to intensive care unit. Then, classified into 2 groups; septic group (25) with well-defined septic shock with positive cultures. Non-septic group (25) with negative cultures or no source of sepsis. Blood samples for SC), C-reactive protein (CRP) and white blood cell count (WBCC) in the first 6 hours of ICU admission and re-obtained again on day 3. We observed the weaning of vasopressor and 7-days in ICU mortality. SC measured on day 1 was significantly higher in the septic group than the non-septic group (p<0.001). SC showed a good correlation with weaning of vasopressor (AUC was 0.764; p<0.028), while it showed relative correlation with 7-days in ICU mortality (AUC was 0.752; p<0.057) compared with other markers in the study. SC may aid in rapid identification of septic shock from non-septic shock at a cutoff of 2 µg/dl (sensitivity 92% and specificity 84%). Also the change in SC level may aid in prognostication of septic shock.
    VL  - 6
    IS  - 3
    ER  - 

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Author Information
  • Critical Care Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

  • Critical Care Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

  • Critical Care Medicine in Alexandria Main University Hospital, Alexandria University, Alexandria, Egypt

  • Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

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